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Saturday, August 28, 2021 | History

4 edition of Biophosphonates in Clinical Oncology found in the catalog.

Biophosphonates in Clinical Oncology

B. Thurlimann

Biophosphonates in Clinical Oncology

The Development in Pamidronate (Recent Results in Cancer Research)

by B. Thurlimann

  • 395 Want to read
  • 37 Currently reading

Published by Springer-Verlag Telos .
Written in English

    Subjects:
  • Oncology,
  • Pharmacology,
  • Disodium pamidronate,
  • Bone Cancer,
  • Clinical Pharmacology,
  • Medical / Nursing,
  • Therapeutic use,
  • Medical,
  • Bones,
  • Cancer,
  • Chemotherapy,
  • Diphosphonates

  • The Physical Object
    FormatHardcover
    Number of Pages113
    ID Numbers
    Open LibraryOL9062399M
    ISBN 103540636897
    ISBN 109783540636892

    Area of expertise, Bisphosphonates / Denosumab, clinical use, Cancer treatment-induced bone loss, Osteoporosis Brendan F Boyce, MB ChB University of Rochester Medical Center Department of Pathology and Laboratory Medicine, Rochester, New York, United States of America.   7. Adjuvant bisphosphonate trials. These studies provided a rationale for testing bone-targeted agents in the adjuvant setting. Despite the initial optimism, results from eight large prospective randomized control studies powered to assess the value of adjuvant bone-targeted therapy in early breast cancer are conflicting (Table 1).   Objective: To research an efficient treatment for the management of bisphosphonate-associated ound Data: Necrosis of the jawbone has recently been described in association with systemic bisphosphonate therapy with drugs including zoledronic acid, pamidronate, and alendronate. The extent and clinical characteristics of bisphosphonate-associated .


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Biophosphonates in Clinical Oncology by B. Thurlimann Download PDF EPUB FB2

Bisphosphonates in Clinical Oncology: The Development of Pamidronate (Recent Results in Cancer Research, ): Medicine Health Science Books Buy Bisphosphonates in Clinical Oncology: The Development of Pamidronate (Recent Results in Cancer Research Book ): Read Kindle Store Reviews - This book provides a clinically oriented overview on the patho-physiological background and the use of bisphosphonates in oncology.

The clinical development of pamidronate to treat tumor-induced hypercalcemia and malignant osteolytic bone disease is demonstrated, as well as. Bisphosphonates in clinical oncology by B.

Thürlimann,Springer edition, in English If you own this book, you can mail it to our address below. You can also purchase this book from a vendor and ship it to our address: Internet Archive Open Library Book Donations Funston Avenue San Francisco, CA Bisphosphonates are also important not only in treating patients with present metastases but also in prevention, or at least, delay of bone metastases onset.

Recently, there are clinical trials examining the so called adjuvant therapy, that means the use of bisphosphonates in prevention of bone metastases in high risk breast cancer patients Author: Vrbanec D, Plestina S, Belev B, Unusić J, Pavlinić-Diminić.

PURPOSE: To determine clinical practice guidelines for the use of bisphosphonates in the prevention and treatment of bone metastases in breast cancer and their role relative to other therapies for this condition.

METHODS: An expert multidisciplinary panel reviewed pertinent information from the published literature and meeting abstracts through May Additional data collected as part of.

PURPOSE: To determine clinical practice guidelines for the use of bisphosphonates in the prevention and treatment of lytic bone disease in multiple myeloma and to determine their respective role relative to other conventional therapies for this condition.

METHODS: An expert multidisciplinary Panel reviewed pertinent information from the published literature through January Values for. Hamilton Regional Cancer Center, Hamilton, Ontario, Canada.

Pierre P. Major, M. is an Biophosphonates in Clinical Oncology book for three clinical trials with biophosphonates sponsored by Novartis and has served on two occasions as an expert advisor.

He is the chairman of the Safety Monitoring Board for. DOI: jco_suppl Journal of Clinical Oncology - published online before print June 1, PMID: Outcomes and utilization patterns of intravenous bisphosphonates for bony metastases in patients with advanced breast cancer: Results in the off-trial setting.

Bisphosphonates were developed in the nineteenth century for industrial use, in particular as water softeners. The first clinical use of bisphosphonates in humans was in the s for the treatment of Paget disease, a focal disorder of bone remodeling due to abnormally increased osteoclast-mediated bone resorption.

This book provides a clinically oriented overview on the patho-physiological background and the use of bisphosphonates in oncology.

The clinical development of pamidronate to treat tumor-induced hypercalcemia and malignant osteolytic bone disease is demonstrated, as well as the results of.

Clinical trial patients also have no identifiable risk factors for ONJ: cancer, chemotherapy, severe periodontal disease, or severe immunosuppression (e.

AIDS). The median time for appearance of ONJ in the oncology area receiving high-dose intravenous bisphosphonates is 25 months. The present article overviews the role of bisphosphonates for the treatment and prevention of bone metastases and their antiangiogenic effects and antitumoral activity.

The skeleton is a frequent a. American society of clinical oncology guideline on the role of bisphosphonates in breast cancer J. Clin. Oncol.18 (), pp. - Google Scholar. Renal safety is an important consideration for oncologists who are treating patients with bisphosphonates.

In recent years, there has been increasing awareness about the development of bisphosphonate-induced nephrotoxicity. This has emerged mainly from increased clinical experience with zoledronic a. Myeloma Bone Disease (Current Clinical Oncology): Medicine Health Science Books Clinical trial results in breast cancer with clodronate were inconclusive, but recent data with zoledronic acid suggest that bisphosphonates may indeed modify the course of the disease.

SUMMARY: The roles of bisphosphonates in metastatic bone disease and the prevention of cancer treatment induced bone loss have been defined. Clinical trial results show that bisphosphonates reduce the occurrence of skeletal complications in patients with breast cancer and bone metastases (Table 1)42 Based on the results of two randomized, placebo-controlled clinical studies in patients with osteolytic bone metastases from breast cancer being treated with either chemotherapy or Cited by: The clinical development of bisphosphonates in oncology has been largely reliant on innovation from academic groups rather than big pharma.

Abstract Bone metastases are common in breast cancer and may cause considerable morbidity including fractures. The clinical and cost considerations of bisphosphonates in preventing bone complications in patients with metastatic breast cancer or multiple myeloma.

Drugs. ;; and from Body JJ, Bartl R, Burckhardt P, et al.for the International Bone and Cancer Study Group. Current use of bisphosphonates in oncology. Purpose: Bisphosphonates are used for treatment or prevention of osteoporosis and of bone metastases.

The use of oral bisphosphonates was suggested to be associated with reduced risk of developing breast cancer, and their positive influence on breast cancer survival was only demonstrated with third-generation bisphosphonates.

We studied the association of use of oral bisphosphonates. Normal skeletal integrity is maintained by physiological bone turnover through a coupled process of bone resorption, mediated by osteoclasts, followed by new bone.

This pre-clinical data is consistent with the results of several clinical studies which have demonstrated a beneficial effect of the adjuvant use of zoledronate in elderly postmenopausal women with cancer, in addition to a role in preventing bone metastases (Mathew and Brufsky,Coleman et al,Chukir et al., Dionisio et al, ).

e Background: Bisphosphonates are the standard therapies used in the prevention of skeletal-related complications in bone-metastatic breast cancer patients. However the optimal duration of bisphosphonate treatment is controversial.

Methods: Ninety-nine female bone metastatic breast cancer patients treated with bisphosphonates (zoledronic acid 4mg or ibandronic. Society of Clinical Oncology. THE AMERICAN Society of Clinical Oncology (ASCO) publishes evidence-based clinical practice guidelines.

As part of the process, the expert panel reviews and updates the guidelines on a regular basis. This document represents an update of the guideline for the use of bisphosphonates in breast cancer that was. Bisphosphonates (BPs, Figure 1) were first synthesized about a century ago by German chemists as antiscaling compounds.

1 Init will be 50 years since the first publications on the biological effects of the BPs. Since then, the BPs have evolved to become one of the most successful and widely used groups of drugs in the world. Bone Cancer: Progression and Therapeutic Approaches.

Bone Cancer. : Dominique Heymann. Academic Press, - Medical - pages. 0 Reviews. The epidemiological and clinical importance of bone metastasis has long been recognized, but the past decade has seen an explosion in the fields of bone biology and bone cancer research.

Hillner BE, Ingle JN, Berenson JR, et al. American Cancer Society of Clinical Oncology guidelines on the role of bisphosphonates in breast cancer.

J Clin. Bisphosphonates have been widely used over the past decade to prevent skeletal complications in breast cancer patients with bone metastases. The skeletal c. Bisphosphonates are endogenous pyrophosphate analogs in which a carbon atom replaces the central atom of oxygen. They are indicated in non-neoplastic diseases including osteoporosis, corticosteroid-induced bone loss, Paget disease, and in cancer-related diseases such as neoplastic hypercalcemia, multiple myeloma and bone metastases secondary to breast and prostate cancer.

Abstract: Bisphosphonates are standard treatment for cancer-induced bone disease, a common feature of many advanced malignancies.

Traditionally used to inhibit bone turnover and reduce the risk of skeletal-related events, there is now increasing pre-clinical evidence that these agents may also affect tumour burden and disease progression. Attending Physician, Thoracic Oncology, University of Torino, San Luigi Hospital in Orbassano, Italy.

from the University of Torino Medical School in Specialty degree in Respiratory medicine at the University of Torino in Member of the American Association of Clinical Oncology. Ontology: pamidronate (C) Definition (NCI_NCI-GLOSS) A drug that is used to treat hypercalcemia (too much calcium in the blood) and cancer that has spread to the bones.

It belongs to the family of drugs called bisphosphonates. Definition (NCI) An amino- bisphosphonate with anti-resorptive and anti-hypercalcemic activities. For the last year, the VCC team has conducted a Zoledronate clinical trial on dogs with bone cancer, and so far, the results are promising.

Zoledronate is one of the most promising bisphosphonate drugs available in veterinary medicine. Zoledronate is administered as a quick 15 minute IV drip, and can provide long-lasting pain control within Sofias Avenue, Athens, Greece.

Abstract: Bisphosphonates inhibit osteoclast-mediated bone resorption and have been used extensively to prevent skeletal-related events in patients with bone lesions from multiple myeloma (MM). In addition, in vitro and in vivo preclinical data suggest that bisphosphonates also have antimyeloma properties.

Bragalone DL () Drug information hand book of oncology, 11th edn. Lexicomp, Inc, Hudson Ohio, pp Google Scholar Von Moos R () Bisphosphonate treatment recommendations for oncologists.

Oncologist Article Google Scholar Download references. Background: Bisphosphonates, which are also known as osteoclast modifiers, are the standard of care in the treatment of skeletal-related events (SREs) in patients with breast cancer with metastatic bone disease.

SREs are frequently a complication of advanced breast cancer, and they greatly increase morbidity and mortality in these patients. Unfortunately, even while undergoing bisphosphonate. Bisphosphonates Bisphosphonates are drugs used to treat bone metabolism disorders such as osteoporosis, bone diseases, and bone pain from some types of cancer.

Bisphosphonates work by inhibiting bone resorption by osteoclasts, they can have side effects in dental treatment, including inhibited tooth movement, impaired bone healing, and induced. Pre-clinical data demonstrated the anti-tumor effects of bisphosphonates alone and to combine theses drugs with other anti-cancer agents.

Syddall, P. Ottewell and I. Holen give an overview of these pre-clinical studies and of the main clinical studies which aimed to determine whether adding bisphosphonates to standard anti-cancer therapy.

Bone disease is the most frequent disease-defining clinical feature of multiple myeloma (MM), with 90 of patients developing bone lesions over the course of their disease. For this reason, imaging plays a major role in the management of disease in patients with MM. Although conventional radiography has traditionally been the standard of care, its low sensitivity in detecting osteolytic.

Bisphosphonates reduce bone turnover by inhibiting osteoclast maturation and function, and are important in the prevention of age-related osteoporosis and bone fracture,1 in the prevention of complications of bone metastases,2 and in the prevention of osteopenia and osteoporosis resulting from adjuvant aromatase inhibitor therapy of breast cancer  Books.

An illustration of two cells of a film strip. Video An illustration of an audio speaker. Use of adjuvant bisphosphonates and other bone-modifying agents in breast cancer: a Cancer Care Ontario and American Society of Clinical Oncology clinical practice guideline.

Item Preview remove-circle Share or Embed This Item. Background: Bisphosphonates are widely prescribed for the prevention and treatment of osteoporosis.

Recent epidemiological studies indicate that people with bisphosphonate use may have lower cancer risk and have improved survival.

The aim of this study is to determine the association between bisphosphonate use and survival outcomes in solid cancer patients using systematic .